Irrfan Khan, who starred in films including Slumdog Millionaire and Life Of Pi, has died of cancer aged 53.
Khan died in a hospital in the western city of Mumbai, his agency said.
He was among the first Indian actors to make a consistent mark in western cinema – and was also known to international audiences for his role in Jurassic World.
In 2018, the actor posted on Twitter to say that he was diagnosed with an endocrine tumour, a rare illness affecting cells that release hormones into the bloodstream.
Khan was initially treated in a London hospital before returning to India in September last year but passed away in Mumbai on Wednesday morning with a colon infection.